ABSTRACT Chalcone is one of the secondary metabolites that has many biological activities such as antimicrobial, antitumor, antioxidant, anti-inflammatory, antimalaria and anticancer. Chalcone can be used as an intermediate for synthesizing heterocyclic coumpounds, such as flavones, flavanols dan flavonones. Generally chalcone can be synthesized from Claisen-Schmidt condensation of ketone and …