SUMMARY Sentul (Sandoricum koetjape (Burm. f.) Merr) is a plant belonging to Meliaceae family. The research aimed to isolate secondary metabolite compounds contained in the leaves and to determine the toxicity. The isolation technique was performed by maceration method using methanol and fractionated with hexane and ethyl acetate. The crude extract of methanol obtained was 20,43 g (0,7%). Th…