Pyrazoline is a five-ring heterocyclic compound containing two nitrogen atoms close to each other and has various biological activities, one of which is antidiabetic. This study aims to synthesize pyrazoline and determine their activity as antidiabetic. Pyrazoline was synthesized from curcumin through a Claisen- Schmidt condensation reaction between 1-benzyl-4-piperidone and 4- chlorobenza…