CD Tesis

Efektivitas Nifedipin, Labetalol, Dan Hidralazin Sebagai Antihipertensi Emergensi Pada Preeklampsia Berat

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Preeclampsia is one of the main causes of maternal morbidity and
mortality with a prevalence of 5-8%. Recently, ACOG has offered nifedipine,
labetalol, or hydralazine as an antihypertensive emergency in preeclampsia.
Labetalol and hydralazine have not been widely used in Indonesia.
Methods: This study was a randomized controlled clinical trial, analytic, doubleblinding,
prospective, and comparative in total of 60 patients who were evenly
divided on each test drug. The study was conducted multicenters at Arifin Achmad
Hospital Riau Province, Tengku Rafian Siak Sri Indrapura Hospital, Dumai
Hospital, and Bengkalis Hospital from May 2021 to April 2022. An analysis of the
decrease in systolic, diastolic, and mean arterial pressure was carried out at the 20th
minute; 40th minute; 60th minute; 2nd hour; 4th hour; and the 6th hour post drug
administration.
Results: The characteristics of pregnant women in this study were 30.65±5 years
old, gravida 1.5±0.7, gestational 31.5±2.8 weeks, had an arm circumference
29.44±2.69 cm, had blood pressure systolic 174.13±13.8 mmHg, diastolic
108.68±17 mmHg, MAP 130.7±12 mmHg, maternal pulse 84±1.4 beats per minute,
and FHR 145.6±6.4 beats per minute. The effectiveness of 1 dose of nifedipine was
comparable to labetalol, but nifedipine was superior to hydralazine with a moderate
difference in effect size. In maintaining blood pressure reduction, the effectiveness
of hydralazine is comparable to nifedipine, but hydralazine is superior to labetalol
with a large effect size difference.
Conclusion: Hydralazine showed the best median time to achieve therapeutic
effect. Nifedipine showed a significant rebound in blood pressure after 4 hours of
drug administration. Nifedipine, labetalol, and hydralazine showed no difference in
subjective and objective side effects.
Keywords: Emergency antihypertensive; Hydralazine; Labetalol; Nifedipine;
Severe preeclampsia.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1810246998

Penerbit

Pekanbaru : Universitas Riau – Pascasarjana – Tesis Pendidikan Dokter Spesialis Obstetri Dan Ginekologi., 2022

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1810246998

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

FATAH

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