CD Skripsi

Sintesis Senyawa Konjugasi Kalkon (E)-1-(4-((3-(1-(7-Klorokuinolin-4-Il)Triaz-2-En-1-Il)Prop-2-Un-1-Il)Oksi)-2-Hidroksifenil)-3(Metoksifenil)Prop-2-En-1-On

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SUMMARY
Organic synthesis has now developed into one of the most important aspects and the main driving force of organic chemistry. With synthesis, natural products can be produced on a large scale in an easy and low-cost way. Through the isolation of natural materials in the modern era and technological advances today, it is possible to synthesize new medicinal compounds based on structural modifications of previously discovered medicinal compounds through the isolation of natural materials. One of them is the synthesis of chalcone compounds (E)-1-(4-((1-(7-chloroquinoline-4-yl)-1H-1,2,3-triazole-4-yl)methoxy) -2-hydroxy phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one via chalcone modification by incorporating a chloroquinoline group with a triazole linker molecule. Synthesis was carried out convergently through the formation of chloroquinoline azides and the formation of propargyl substituted chalcones. These two compounds were then combined through the formation of a linking compound, namely triazole, which was carried out by "click chemistry". The yield obtained from the chalcone synthesis was 28.90 %. The low yield is because the synthesized compound is an intermediate product, which is a minor product. The interpretation results of UV, FTIR, 1H-NMR, 13C-NMR and HR-MS data indicated that the synthesized compound was (E)-1-(4-((3-(1-(7-chloroquinoline-4-yl)triaz-2-en-1-yl))prop-2-un-1-yl)oxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one. This compound is an intermediate compound of the target molecule.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1603115869

Penerbit

Pekanbaru : Universitas Riau - FMIPA - KIMIA., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1603115869

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

tethi

Versi lain/terkait

Lampiran Berkas

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