CD Skripsi

Aktivitas Antidepresan Ekstrak N-Heksana Biji Pinang Muda Dengan Metoda Forced Swim Test Pada Mencit Jantan (Mus Musculus) Yang Diuji Secara Simultan

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SUMMARY
Depression is a mental disorder caused by an imbalance of neurotransmitters which
can be treated with antidepressants. The method commonly used for antidepressant
screening which is validated by animal behavior is the Forced Swim Test (FST). It
has not been clarified the antidepressant activity of n-hexane extract young areca
nut (Areca catechu L.) through FST using a single test animal and multiple test
animals simultaneously. Therefore, this study aimed to perform FST on two mice
simultaneously to see how the presence of a demonstrator affected the test subject’s
behavior, which had been injected acutely and sub-chronically with young areca
nut n-hexane extract. The young areca nut n-hexane extract was injected
intraperitoneally 1 hour before FST to mice (test subject) at doses of 10, 50, and
100 mg/kg, while the demonstrator was only injected 0.9% saline. The lowest
immobility time was caused by a dose 50 mg/kg with a percentage of reduction
immobility time 31.37%. The best dose of n-hexane extract can still reduce
immobility time though test subject tested simultaneously. It was indicated by there
was no decline in the reduction of immobility time in the FST of multiple test
animals. The results of the phytochemical analysis stated that the saponins and
steroids present in the young areca nut n-hexane extract may be the active
constituents that act as antidepressants. No toxic effects were detected from the
young areca nut n-hexane extract in mice that had been injected for 7 consecutive
days. Based on the statement above, it can be concluded that the young areca nut
n-hexane extract at a dose of 50 mg/kg has the potential as an antidepressant without
causing toxic effects.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903110864

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903110864

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

TIAR

Versi lain/terkait

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