CD Skripsi

Isolasi Senyawa Metabolit Sekunder Ekstrak Diklorometana Dan Uji Aktivitas Antijamur Dari Tumbuhan Akar Kuning (Arcangelisia Flava (L.))

---

SUMMARY
Yellow root (A. flava) is a plant that grows on the Indonesian islands of Sumatera and Kalimantan. This plant belongs to the Menispermaceae genus and is widely used in traditional medicine due to its antibacterial, anti-inflammatory, and anti-diabetic properties. The objectives of this research are to isolate a secondary metabolite compound from an A. flava dicloromethane extract and tested its antifungal activity. The compound was obtained from an A. flava isolate that was macerated for two days, partitioned using dicloromethane, and separated further using VLC to yield nine main fractions. Fraction 2, which is a recrystallization of fractions 3 to 4, yields a pure compound. This pure compound then coded as compound 22-10-B-FII. Through analysis of purity, a stain on thin layer chromatography (TLC) plate after dripping with anisaldehyde and heating, one dominant peak at retention time of 21,822 minute using HPLC and melting point of 240-241°C were obtained and it could be concluded that compound 22-10-B-FII was pure. Compound 22-10-B-FII was then characterized using a UV-Vis spectrophotometer, FT-IR, and NMR spectroscopy. The UV-Vis spectrum showed maximum absorption at 211 nm with an absorbance of 0,705. The wave numbers obtained by FT-IR analysis were 3464 cm-1, 2989 cm-1, 2968 cm-1, 2360 cm-1, 1768 cm-1 and 1693 cm-1. Compound 22-10-B-FII was identified as fibraurin, a terpenoid, through characterization. Compound 22-10-B-FII demonstrated antifungal activity against Candida albicans, C. glabrata, and C. krusei, with the same MIC value of 25 μg/mL and MFC values of 50 μg/mL, 100 μg/mL, and 100 μg/mL, respectively.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

1903155447

Penerbit

Pekanbaru : Universitas Riau - FMIPA - Kimia., 2023

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

1903155447

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

TETHI

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar