CD Skripsi

Sintesis Dan Studi Molecular Docking Senyawa 2-Naftalenil Kalkon Tersubstitusi Morfolin Sebagai Kandidat Obat Antikanker Payudara

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Chalcone is a compound composed of two aromatic rings bonded via three carbons which are composed of carbonyl groups and unsaturated α-β bonds which have played a role in various biological activities such as anticancer. Chalcone derivatives of 2-acetylnaphthalene and 4-hydroxybenzaldehyde substituted for morpholine had been successfully synthesized via the Claisen-Schmidt reaction and followed by O-alkylation. The morpholine substituted chalcone compound was synthesized by stirring and heating at a temperature of 60-70°C for 14 hours and purified by recrystallization to produce a pale white crystalline solid with a yield of 63.74%. The structure of the target synthesis compound was analyzed and confirmed through UV, FTIR, LCMS, 1H-NMR, and 13C- NMR. The in silico test was carried out on CLN-2NFT-4OM (20) as a breast anticancer agent through molecular docking of the estrogen receptor α (PDB ID:8DVB) with a positive control, namely 4-hydroxytamoxifen (4OHT). The results of the anticancer activity of CLN-2NFT-4OM (20) and the positive control respectively through molecular docking analysis showed quite good inhibition of the estrogen receptor α by showing binding free energy (∆Gbind) data and an inhibition constant of -9.4 kcal/mol and 1.26 μM and -9.3 kcal/mol and 1.27 μM. These results are close enough between the target compound and the positive control indicating that the compound chalcone CLN-2NFT-4OM (20) has the potential to act as an inhibitor of estrogen receptor α which triggers as a cause of breast cancer

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903111778

Penerbit

Pekanbaru : Universityas Riau – FMIPA – Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903111778

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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