CD Skripsi

Sintesis Dan Uji In Silico Senyawa Pirazolin Turunan 1-Hidroksi-2-Asetilnaftalena Dengan 3-Klorobenzaldehid Dan Fenilhidrazin Sebagai Antikanker Payudara

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Pyrazoline is an azole compound in the form of heterocyclic rings consisting of three C and two N atoms. Pyrazoline compound has a wide range of bioactivities. This study aims to analyse the anti-breast cancer activity of 2-(5-(3-chlorophenyl)-1-phenyl-4,5dihydro-1H-pyrazol-3-yl)naphthalen-1-ol (PF-NH1-3Cl) pyrazoline compound against the α-estrogen receptors. The PF-NH1-3Cl compound had been successfully synthesized in two step. The first step was synthesis of chalcone compound 3-(3-chlorophenyl)-1-(1-hydroxynaphthlen-2-yl)prop-2-en-1-one and the second step is synthesis PF-NH1-3Cl compound. The method used in the synthesis of PF-NH1-3Cl compound was a stirring at high temperature at 70-80oC for two hours with a yield of 69,91%. The purity of the compounds was tested by measuring the melting point of 179-180oC, thin layer chromatography method (TLC) and high performance liquid chromatography analysis (HPLC). The PF-NH1-3Cl compound structure was confirmed by ultraviolet (UV), Fourier transform infrared (FTIR), liquid chromatography mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy characterization. The activity of PF-NH1-3Cl compound was determined by in silico tests on α-estrogen receptors. The result of molecular docking showed that the compound PF-NH1-3Cl could inhibit the binding of the hormone estrogen with Gibbs free energy (ΔG¬¬bind) and the inhibition constant (Ki) of -10,2 kcal/mol and 0,033 µM.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903112950

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903112950

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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