CD Skripsi

Sintesis Dan Uji In Silico Senyawa Pirazolin Turunan 2-Klorobenzaldehid Dan 1-Hidroksi-2-Asetilnaftalen Sebagai Obat Kanker Payudara

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Pyrazoline is a dihydropyrazole derivative which is an azol group compounds with a heterocyclic-5 structure containing 2 nitrogen atoms. Pyrazoline compounds are known have toxic properties and various bioactivities, one of which was as an anticancer agent. 2-(5-(2-chlorophenyl)-1-phenyl-4,5dihydro-1H-pyrazol-3-yl)naphthalen-1-ol (PRZ-NFT-2Cl) has successfully synthesized with two step reaction. The reaction begins with the formation of chalcone compounds 3-(2-chlorophenyl)1-(1-hydroxynaphthalene-2-il)-2-propen-1-one by reacting 1-hydroxy-2-acetylnaphthalene and 2-chlorobenzaldehyde using the microwave irradiation method. Chalcone synthesis through the Claisen-Schmidt condensation reaction with a yield of 57%. Chalcone was reacted with phenylhydrazine to produce the target compound using potassium hydroxide as a catalyst. The method of synthesis of the target compound used the stirrer and heating with the tool pressure, resulted in a yield of 83.41%. The target pyrazolin compound was purified by recrystallization and then tested for purity using KLT test, melting point and HPLC analysis. The structure of the synthesized compound obtained was confirmed through FTIR, UV, LC-MS, 1H-NMR, and 13C-NMR spectroscopic studies. The results of molecular docking of PRZ-NFT-2Cl compound reveal that the compound could inhibit the binding of the hormone estrogen α with free binding energy (∆Gbind) and an inhibitions constant (Ki) respectively -9.5 kcal / mol and 0.108 μM.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903113541

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903113541

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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