CD Skripsi

Sintesis Pirazolin 5-(2-Bromofenil)-3-(1- Hidroksinaftalen-2-Il)-1- Fenil-4,5-Dihidro-1h- Pirazol Dan Studi In Silico Sebagai Agen Antikanker

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Pyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which is known to have diverse biological activities such as antioxidant, antitumor and anticancer agent. Pyrazoline (5-(2-bromophenyl)-3-(1-hydroxynaphthalene-2- yl)-1-phenyl-4,5-dihydro-1H-pyrazole has successfully synthesized with several phases of reaction. The reaction begins formation of chalcone 3-(2-bromophenyl)- 1-(1-hydroxynaphthalene-2-yl)-2-propen-1-on by reacting 1-hydroxy-2-acetyl naphthalene compound with 2-bromobenzaldehide using microwave irradiation method. Chalcone synthesis through Claisen-Schmidt condensation reactions with yield 85 %. The next stepwas reacted chalcone with phenyl hydrazine to produce target compound used sodium hydroxide catalyst with a monowave for 3 hours at a temperature of 80℃ and the resulting yield was 81%. The purity of the target compound was determined using TLC, melting point and HPLC. Analysis and confirming its structure based on spectroscopic data of UV, FTIR, 1H-NMR, 13C-NMR and LCMS. Furthermore, the results of the synthesis of the PF-NH1-2Br compound were studied in silico using the molecular docking method by looking at the interaction between the target compound as a ligand for the estrogen receptor α (ERα) PDB ID: 3ERT. The interaction of the target compound with the estrogen receptor α shows a free binding value (∆Gbind) of -10.73 kcal/mol and an inhibition constant (Ki) value of 13.71 nM.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1903111673

Penerbit

Pekanbaru : Universitas Riau – FMIPA - Kimia., 2023

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1903111673

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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