CD Skripsi

Sintesis Turunan Hidrazon Tersubstitusi 1-Asetilnaftalena Dan 2-Metoksibenzaldehid Menggunakan Benzhydrazide Dan Uji In Silico Sebagai Agen Antikanker Paru-Paru

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Hydrazones are compounds formed from the replacement of the carbonyl group in aldehydes or ketones by condensation reactions with hydrazine. Hydrazone compounds have various activities, one of which is anticancer activity. This research aims to synthesized the hydrazone derivative compound (E)-N'-((E)-3-(2- methoxyphenyl)-1-(naphthalene-1-yl)allylidene)benzohydrazide and carry out in silico tests to determined its anti-lung cancer activity. The HDZ-1NFT-2OMe compound has been successfully synthesized in two stages. The first stage was the synthesis of the chalcone compound (E)-3-(2-methoxyphenyl)-1-(naphthalene-1- yl)prop-2-en-1-one and the second stage was the synthesis of the compound HDZ- 1NFT-2OMe. The method used in the synthesis of the HDZ-1NFT-2OMe compound was stirring at high temperature at 70-80oC for six hours with a yield of 69,2%. The purity of the compound was tested through melting point measurements, thin layer chromatography (TLC) methods, and high performance liquid chromatography (HPLC) analysis. The structure of the pure HDZ-1NFT- 2OMe compound was confirmed through ultraviolet (UV), Fourier transform infrared (FTIR), liquid chromatography mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy characterization. The activity of the HDZ-1NFT-2OMe compound was carried out through an in silico molecular docking test against the epidermal growth factor receptor (EGFR). The results of molecular docking show that the HDZ-1NFT-2OMe compound can inhibit EGFR receptor binding with a Gibbs free energy (ΔGbind) and inhibition constant (Ki) of
-10.6 kcal/mol and 0.014 µM, respectively.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2003112902

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2003112902

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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