CD Skripsi

Isolasi Dan Uji Antijamur Senyawametabolit Sekunder Dari Ekstrak Kloroform Pada Tanaman Paku (Drynaria Sparsisora)

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Drynaria sparsisora is an epiphytic fern species belonging to the Polypodiaceae family. Several species within this genus have been reported to exhibit anti- inflammatory, anticancer, antimicrobial, antifungal, and antiviral properties. This study aimed to isolate secondary metabolites from the chloroform extract of D. sparsisora and evaluate their antifungal activity. The chloroform extract was obtained through maceration and subsequent vacuum liquid chromatography (VLC), yielding eight fractions. Fraction 5 from VLC was further purified using flash chromatography, resulting in 15 major subfractions. Thin-layer chromatography (TLC) analysis of subfraction 12 revealed a single spot under UV light at 254 nm and 366 nm, as well as upon visualization with anisaldehyde. The compound exhibited a melting point of 179-181°C. High-performance liquid chromatography (HPLC) analysis confirmed the purity of the isolated compound, designated as 23-11-B-FV-SF12-400-404/511. Structural elucidation was performed using UV-Vis, FTIR, and NMR spectroscopy. The spectroscopic data suggested that the isolated compound was structurally similar to caffeic acid. The antifungal activity of the extract, fractions, and isolated compound was evaluated using the microdilution method against three fungal strains: C. albicans, C. glabrata, and C. krusei. The results demonstrated promising antifungal activity against these pathogenic fungi.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2003114074

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2024

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2003114074

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

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