CD Skripsi

Sintesis Dan Uji In Silico Senyawa Hidrazon (E)-2-((E)-1-(Naftalen-2-Il)-3-(4-Nitrofenil)Alliliden) Hidrazin-1-Karboksamida Sebagai Kandidat Antikanker Serviks Dan Payudara

---

Hydrazone compounds belonged to the azomethine group, characterized by a distinctive chain (-NHN=CH-). As analogs of Schiff bases, hydrazones exhibited promising pharmacological properties, including potential anticancer activity. This study aimed to synthesize the hydrazone compound, (E)-2-((E)-1-(naphthalen-2- yl)-3-(4-nitrophenyl)allylidene)hydrazine-1-carboxamide and to evaluate its anticancer potential against cervical and breast cancer through in silico molecular docking. The hydrazone compound HSC-2NFT-4NO2 (19) was successfully synthesized through two step reaction. The first step involved the formation of chalcone (12) via Claisen-Schmidt condensation reaction using the microwave method at 180 watts, and the second step involved the formation of the hydrazone compound using the stirring method at 70–80 °C for 7 hours. The respective yields were 53,1% and 83,6%. The purity of each synthesized compound was confirmed using TLC, melting point analysis, and HPLC analysis. Structural confirmation of the final product was achieved through UV, FTIR, MS, ¹H-NMR, and ¹³C-NMR spectroscopic data. In silico analysis using molecular docking revealed that HSC-2NFT-4NO2 (19) exhibited potential as an inhibitor of SIRT1 and ER-α proteins, with better binding affinity (ΔGbind) and inhibition constant (Ki) values compared to their respective positive controls. Compounds with lower ΔGbind and Ki indicated better anticancer potential and a reduced risk of side effects. The compound showed ΔGbind and Ki values against cervical cancer of -12,44 kcal/mol and 0,0075 µM, respectively, which were better than those of EX527 at -9,25 kcal/mol and 1.64 µM. Against breast cancer, the compound showed values ΔGbind and Ki of -8,8 kcal/mol and 0,35 µM, respectively, which were also better than those at 4-OHT -6,8 kcal/mol and 10,30 µM.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2103110141

Penerbit

Pekanbaru : Universitas Riau FMIPA Kimia., 2025

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2103110141

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

KIMIA

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Mutia

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar