Image of Efek Pemberian Ekstrak Daun Aren (Arenga Pinnata) Pada Tikus Jantan (Rattus Norvegicus) Model Diabetes: Analisis Histopatologi Mukosa Lambung
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Efek Pemberian Ekstrak Daun Aren (Arenga Pinnata) Pada Tikus Jantan (Rattus Norvegicus) Model Diabetes: Analisis Histopatologi Mukosa Lambung

Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in carbohydrate, fat, and protein metabolism resulting from impaired insulin secretion, insulin action, or both. Elevated blood glucose levels (hyperglycemia) are the hallmark of DM. This study aimed to evaluate the effect of Arenga pinnata leaf extract on the histopathological features of the gastric mucosa in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. An experimental study with a post-test only control group design was conducted using 30 male Wistar rats, divided into five groups (n=6): normal control, diabetic control, and three diabetic groups treated orally with Arenga pinnata leaf extract at doses of 500, 1000, and 1500 mg/kgBW for two weeks. Gastric mucosal histopathology was assessed using the modified Barthel Manja scoring sistem. Data were analyzed using the Shapiro- Wilk test for normality, Levenee’s test for homogeneity, the Kruskal-Wallis test, and post hoc (pairwise comparisons). The diabetic group exhibited gastric mucosal damage characterized by desquamation, erosion, and ulceration. Administration of Arenga pinnata leaf extract significantly reduced histopathological damage compared to the diabetic control group (p < 0.05). The 1500 mg/kgBW dose provided the most optimal improvement, with gastric mucosal appearance approaching that of the normal control group. Arenga pinnata leaf extract has the potential to ameliorate gastric mucosal damage in diabetic rat models, administration of the extract at a dosage of 1500 mg/kgBW exhibited the most optimal protective effect.


Keywords: Arenga pinnata, DM, gastric mucosa, gastric histopathology, streptozotocin.

Ketersediaan
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Perpustakaan Universitas Riau 2208111010
2208111010
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Informasi Detail
Judul Seri
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No. Panggil
2208111010
Penerbit
Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran.,
Deskripsi Fisik
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Bahasa
Indonesia
ISBN/ISSN
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Klasifikasi
2208111010
Tipe Isi
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Tipe Media
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Tipe Pembawa
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Edisi
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Subjek
PENDIDIKAN KEDOKTERAN
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Pernyataan Tanggungjawab
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