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Studi Histopatologi Hepar Tikus Wistar (Rattus Norvegicus) Model Diabetes Melitus Setelah Pemberian Ekstrak Daun Aren (Arenga Pinnata)

Diabetes Mellitus (DM) is a state of hyperglycemia that triggers oxidative stress that can cause liver damage characterized by reversible and irreversible damage to hepatocyte cells. Sugar palm leaf (Arenga pinnata) extract contains flavonoid compounds which have antidiabetic effects. This study aims to determine the effect of administering sugar palm leaf extract (Arenga pinnata) on the histopathology of the liver of Wistar rats (Rattus norvegicus) induced by type 2 diabetes mellitus with streptozotocin (STZ) and nicotinamide (NA). The study was experimental with a posttest-only control group design using 25 male rats divided into 5 groups, namely: normal rats (KN), DM-induced rats (K(-)), DM-induced rats and sugar palm leaf extract doses of 500, 1000, and 1500 mg/kgBW (K1, K2, and K3). The staining used was Hematoxylin-Eosin (HE) and liver histopathology was assessed using the Manja Roenigk score based on four levels of hepatocyte cell damage, namely: normal, parenchymatous degeneration, hydropic degeneration, and necrosis. Data were analyzed statistically to compare differences between groups. The results showed a significant difference between K(-) with K2 and K3 (p=0.036 and p=0.013) that indicate changes in liver histopathology. The conclusion of the study is that sugar palm leaf extract (Arenga pinnata) has a significant hepatoprotective effect on liver histopathological damage in Rattus norvegicus rats diabetes mellitus model.

Keywords: Arenga pinnata leaves, Diabetes Mellitus, Histopathology, Liver, Rattus norvegicus

Ketersediaan
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Perpustakaan Universitas Riau 2208112462
2208112462
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Informasi Detail
Judul Seri
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No. Panggil
2208112462
Penerbit
Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran.,
Deskripsi Fisik
-
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
2208112462
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN KEDOKTERAN
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Pernyataan Tanggungjawab
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