CD Skripsi

Efek Nano-Kurkumin Terhadap Gambaran Histopatologi Ketebalan Miometrium Pada Hewan Model Adenomiosis

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Adenomyosis, characterized by the invasion of endometrial tissue into the myometrium resulting in myometrial hypertrophy, is a gynecological disorder that requires new therapeutic approaches. This study aimed to evaluate the therapeutic potential of Nano-Curcumin, a high-bioavailability formulation possessing potent anti-inflammatory properties, against adenomyosis parameters in a rat model. The method used was an in vivo experimental design where adenomyosis model rats were divided into a negative control group and nano-curcumin therapy groups at doses of 50 mg/kgBW and 100 mg/kgBW. The therapy was administered orally, followed by the measurement of final body weight (BW), uterine weight, and histopathological analysis of myometrial thickness. The results showed that the nano-curcumin therapy groups experienced an increase in body weight (indicating metabolic improvement) and a significant reduction in uterine weight, where the 100 mg/kgBW dose provided the most optimal effect in lesion reduction and inflammation suppression. Although the uterine weight-to-body weight ratio did not differ significantly between groups, nano-curcumin proved to have a positive influence on reducing myometrial thickness. It was concluded that Nano-Curcumin possesses effective therapeutic potential for managing adenomyosis, with the 100 mg/kgBW dose being the most effective in reducing uterine weight and improving the myometrial histopathological profile in the animal model.

Keywords: Adenomyosis, Antioxidant, Anti-inflammatory, Curcumin, Estrogen, Myometrium, Nanocurcumin, Oxidative stress, VEGF

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2208124743

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2208124743

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

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