Image of Pengaruh Pemberian Nanokurkumin Terhadap Ekspresi Protein Hoxa10 Pada Tikus Model Adenomiosis
Penanda Bagikan

CD Skripsi

Pengaruh Pemberian Nanokurkumin Terhadap Ekspresi Protein Hoxa10 Pada Tikus Model Adenomiosis

Adenomyosis is a benign gynecological disorder characterized by the presence of endometrial glands and stroma within the myometrium, frequently associated with infertility. Reduced endometrial receptivity in adenomyosis has been linked to the downregulation of key implantation markers, including HOXA10. Curcumin was known to exert anti-inflammatory effects primarily through inhibition of the NF-κB pathway, however, its poor oral bioavailability limited clinical applicability. Nanocurcumin formulations enhanced absorption, yet their therapeutic effect on HOXA10 in adenomyosis has not been previously evaluated. This study aimed to determine the effect of nanocurcumin on HOXA10 in the eutopic endometrium of adenomyosis model rats. A post-test only control group design was conducted using 17 Rattus norvegicus Wistar rats. Adenomyosis was induced using fluoxetine for 90 days. Rats were then allocated into a control group and two treatment groups receiving nanocurcumin for 14 days. HOXA10 expression was assessed using immunohistochemistry and quantified using H-Score analysis via ImageJ. Nanocurcumin significantly increased HOXA10 in glandular epithelial cells compared with controls (p < 0.001), with no significant difference between the two treatment doses. Conversely, stromal HOXA10 showed no significant change across groups (p = 0.721). These findings suggest compartment-specific responsiveness and support further investigation into nanocurcumin as a potential non-invasive therapeutic modality for adenomyosis.

Keywords: Adenomyosis, HOXA10, nanocurcumin, immunohistochemistry, endometrial receptivity.

Ketersediaan
#
Perpustakaan Universitas Riau 2208112082
2208112082
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
2208112082
Penerbit
Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran.,
Deskripsi Fisik
-
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
2208112082
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN KEDOKTERAN
Info Detail Spesifik
-
Pernyataan Tanggungjawab
Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas
Komentar
Anda harus masuk sebelum memberikan komentar