CD Skripsi

Analisis Hubungan Ekspresi Gen X-Ray Repair Cross Complementing 1 (XRCC1) Dan Profil Pasien Kanker Endometrium

---

Endometrial cancer is a malignancy from the epithelial lining of the uterus and ranks as the sixth most common cancer among women worldwide. DNA damage plays an important role in carcinogenesis, especially in endometrial cancer, thereby requiring DNA repair mechanisms in which the X-ray Repair Cross-Complementing 1 (XRCC1) gene takes a pivotal role in maintaining genomic stability through the base excision repair pathwa.. This study aimed to analyze the differences in XRCC1 gene expression between normal and cancerous endometrial tissues ; to evaluate its association with patients’ clinical profiles. This was an analytic study with a cross-sectional design using mRNA sequencing data obtained from the TCGA, GDC, and Cbioportal databases. Statistical analyses were performed using the Mann–Whitney, Kruskal–Wallis, and Kaplan–Meier tests. The results showed that XRCC1 gene expression was significantly higher in endometrial cancer tissues compared to normal tissues (p < 0,05). No significant associations were found between XRCC1 expression and clinical parameters such as age, stage, histological grade, molecular classification, histopathological type and survival.
Keywords : Endometrial cancer, XRCC1, gene expression, DNA repair, survival.

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2208156185

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2208156185

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar