CD Tesis

analisis pengaruh komorbid dan kejadian efeksamping obat regimen bpAlm terhadap hasil pengobatan pasien tuberkulosis resisten obat

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Background : Indonesia have a high burden of drug-resistant tuberculosis
(DR-TB), yet new case finding is still below national estimates. Challenges such
as limited facilities, drug unavailability, presence of comorbidities and incidence
of adverse drug events may hinder treatment success. In 2022, the World Health
Organization (WHO) recommended a BPaLM regimen with shorter treatment
duration and promising effectiveness. Although it will be implemented in
Indonesia in 2023, data on its effectiveness, safety and the influence of
comorbidities and adverse events are still limited. This study analyzed the effect of
comorbidities and adverse drug events of the BpaLM regimen on the success of
DR-TB treatment in Riau Province.
Methods : This study used an observational analytic design. Data on DRTB
patients undergoing BPaLM regimen treatment between January 1 and
December 31, 2024 in Riau Province were obtained from the Health Office, SITB
and interviews using questionnaires. Information including demographic data,
comorbidities, nutritional status, socioeconomics, smoking status, TB history,
comorbidity and incidence of adverse events were collected and analyzed.
Results : A total of 122 DR-TB patients treated with the BPaLM regimen in
Riau Province in 2024, 57 patients who completed treatment by the end of 2024
were included in this study. The treatment success rate reached 84.21% with a
predominance of sputum conversion time < 2 months (84%). The highest
treatment success was recorded in patients without comorbidities (92.31%) and
patients with normal body mass index (88.89%). Adverse drug events occurred in
61.40% of patients and did not affect treatment success (p > 0.05). Comorbid
heart disease had a significant influence on treatment outcomes (p = 0.003).
Conclusion : The use of the BPaLM regimen in Riau Province showed high
treatment success rates with a predominance of rapid sputum conversion times
indicating the effectiveness of this regimen in controlling infection. Comorbid
heart disease can affect treatment outcomes, so comorbid management is
important to improve the success of DR-TB therapy.
Keywords : Drug-resistant tuberculosis, BPaLM regimen, treatment success,
comorbidities, side effects.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1910247808

Penerbit

Pekanbaru : UNRI – PASCA – Pulmonologi dan Kedokteran Respirasi., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

1910247808

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Spesialis Pulmonologi dan Kedokteran Respirasi

Info Detail Spesifik

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Pernyataan Tanggungjawab

Rahmat

Versi lain/terkait

Lampiran Berkas

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