CD Skripsi

Pengaruh Hidrolisat Protein Dari Puduong Terhadap Perlemakan Hati Tikus Yang Diinduksi Diet Tinggi Lemak

---

Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by the accumulation of triglycerides >5% in hepatocytes. In Indonesia, the prevalence reaches 51%. Dietary interventions and functional foods are widely studied approaches as prevention strategies. Puduong, a traditional fermented food made from Pangasius sp., contains protein hydrolysates rich in bioactive peptides that have the potential to modulate lipid metabolism and oxidative stress. This study aims to assess the effect of protein hydrolysates from puduong on preventing hepatic steatosis in rats induced by a high-fat diet (HFD). This experimental study used a posttest-only control group design with 24 male rats divided into five groups: standard diet, HFD, HFD plus atorvastatin, HFD plus puduong protein hydrolysate 25 mg/kgBW, and 50 mg/kgBW. After treatment, liver tissue was examined using Hematoxylin-Eosin staining and the percentage of steatosis and NAFLD Activity Score (NAS) were measured. The results showed that the high-fat diet group experienced increased steatosis (average 9.40%), while the puduong group with a dose of 25 mg/kgBW showed a lower mean steatosis (4.50%) compared to atorvastatin (6.20%). The 50 mg/kgBW group showed the highest mean steatosis (11.40%). All groups had NAS scores in the Not MASH category. One-Way ANOVA test showed no significant difference between groups (p = 0.334). In conclusion, protein hydrolysate from puduong with a dose of 25 mg/kgBW showed a potential protective effect against steatosis, but it was not statistically significant.

Key words: high-fat diet, MASLD, protein hydrolysate, puduong, steatosis

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2208112439

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2208112439

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar