CD Skripsi

Efek Ekstrak Inulin Umbi Dahlia Terhadap Ekspresi Vcam-1 Pada Tikus Diabetes Melitus Tipe 2

---

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia that leads to endothelial dysfunction and accelerates atherosclerosis. Vascular Cell Adhesion Molecule-1 (VCAM-1) plays a key role in this process. Inulin, a prebiotic fiber from dahlia tubers, has anti-inflammatory properties through inhibition of the NF-κB pathway. This experimental study aimed to evaluate the effect of dahlia tuber inulin extract on VCAM-1 expression in the abdominal aorta of Wistar rats with type 2 diabetes mellitus. Twenty five rats were divided into five groups: control, type 2 diabetes mellitus, and type 2 diabetes mellitus treated with inulin extract at doses of 0.5, 1, and 1.5 mg/gBW. Diabetes was induced with streptozotocin (60 mg/kgBW) and nicotinamide (120 mg/kgBW). The extract was administered orally for 21 days. VCAM-1 expression was examined immunohistochemically and quantified using Adobe Photoshop. The mean VCAM-1 area was highest in the type 2 diabetes mellitus group (11.5 ± 3.88%) and lowest in the 1.5 mg/gBW group (5.95
± 1.82%), showing a significant difference (p < 0.05). These findings suggest that dahlia tuber inulin extract, especially at 1.5 mg/gBW, significantly reduces VCAM-1 expression, potentially providing vascular protective effects in type 2 diabetes mellitus.
Keywords :VCAM-1, inulin, dahlia tuber, type 2 diabetes mellitus

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

2208112456

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

-

Bahasa

Indonesia

ISBN/ISSN

-

Klasifikasi

2208112456

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

-

Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar