CD Skripsi

Efek Ekstrak Inulin Umbi Dahlia Terhadap Ketebalan Tunika Intima Media Aorta Torakalis Pada Tikus Diabetes Melitus Tipe 2

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Inulin is a natural polysaccharide that can enhance glucose metabolism and reduce cholesterol levels through the formation of short-chain fatty acids. These effects are thought to prevent atherosclerosis, one of the chronic complications of type 2 diabetes mellitus (T2DM). This study aimed to determine the effect of inulin extract from dahlia tubers on the thickness of the thoracic aorta intima-media in male rats (Rattus norvegicus) with T2DM. This experimental laboratory study used a post-test only control group design with 20 male Wistar rats aged 2–3 months, divided into five groups. T2DM was induced using Streptozotocin (60 mg/kgBW) and Nicotinamide (120 mg/kgBW). The inulin extract was administered orally for 21 days at doses of 0.5 mg/gBW, 1.0 mg/gBW, and 1.5 mg/gBW. The thickness of the intima-media was measured using a light microscope with hematoxylin-eosin staining. Statistical analysis showed no significant differences among the treatment groups (p = 0.051), although a decreasing trend in intima-media thickness was observed at the 1.5 mg/gBW dose. It can be concluded that administration of inulin extract from dahlia tubers at various doses did not have a significant effect on the thickness of the thoracic aorta intima-media in male rats with type 2 diabetes mellitus.

Keywords: inulin, dahlia tuber, type 2 diabetes mellitus, intima-media thickness, thoracic aorta

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2208135530

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2208135530

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

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