CD Skripsi

Pengaruh Ekstrak Daun Kersen (Muntingia Calabura) Terhadap Aorta Tikus Wistar Jantan Yang Diinduksi Diet Tinggi Lemak

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Atherosclerosis is a chronic inflammatory disease caused by endothelial dysfunction and lipid accumulation, which can be triggered by a high-fat diet. This study aimed to assess the effect of kersen leaf extract (Muntingia calabura) on the degree of atherosclerosis in male Wistar rats, histopathologically. Fifteen rats were randomly divided into three groups (n=5): P1 (standard diet), P2 (high-fat diet), and P3 (high-fat diet + kersen leaf extract). The extract was given orally at a dose of 100 mg/kgBW for eight weeks. Aortic tissue was examined histopathologically with hematoxylin-eosin staining, and the degree of atherosclerosis was assessed using semi-quantitative scoring. Data analysis was performed using the Kruskal-Wallis and Mann-Whitney tests. The mean atherosclerosis grades were 0.00 ± 0.00 (P1), 1.60 ± 0.55 (P2), and 0.80 ± 0.84 (P3), respectively. The Kruskal-Wallis test showed a significant difference between groups (p=0.011), and the Mann–Whitney test showed a significant difference between P1 and P2 (p=0.005), but not between P2 and P3 (p=0.118), or P1 and P3 (p=0.053). Kersen leaf extract showed a mild protective effect on atherosclerosis scores in mice fed a high-fat diet, but the effect was not statistically significant. Higher doses and longer treatment durations are needed to optimally evaluate its therapeutic potential.

Keywords: kersen leaves, high-fat diet, atherosclerosis, antioxidants, inflammation

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2208111044

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2208111044

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

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