CD Skripsi

Analisis Ekspresi Gen Partner And Localizer Of Brca2 Pada Kanker Endometrium

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Endometrial cancer is a malignancy that develops in the epithelial lining of the endometrial cancer. Previous studies have suggested a potential involvement of the Partner and Localizer of BRCA2 (PALB2) gene in the development of endometrial cancer. This indicates that PALB2 may contribute to the pathogenesis of endometrial cancer and could be considered a potential biomarker. This study aimed to analyze the differences in PALB2 gene expression between normal endometrial tissues and endometrial cancer, to evaluate the variations in gene expression among different ages, histological grade, stages, histopathological type, molecular subtype, as well as to assess the association between gene expression levels and overall survival. Patients data were obtained from the TCGA, GDC, and cBioPortal datasets, using an analytical cross sectional study design and a total sampling technique. The result of this investigation demonstrated that majority of endometrial cancer patients were 61-70 years old, diagnosed at an early stage, classified as having a high histological grade, of histopathological type 1, and classified as the NSMP/cnl molecular subtype. In conclusion, PALB2 gene expression was significantly higher in endometrial cancer compared to normal endometrial tissue (p = 0,007). PALB2 expression was also significantly associated with grade (p = 0,000), stage (p = 0,007), histopathological type (p = 0,000), and molecular subtype (p = 0,009) of endometrial cancer. Furthermore, higher PALB2 expression was significantly associated with poorer overall survival (72%) compared to lower expression (83%).


Keyword : endometrial cancer, PALB2 gene expression

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2208112433

Penerbit

Pekanbaru : Universitas Riau – Fakultas Kedokteran - Pendidikan Kedokteran., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2208112433

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN KEDOKTERAN

Info Detail Spesifik

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Pernyataan Tanggungjawab

Vina

Versi lain/terkait

Lampiran Berkas

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