CD Skripsi
pengaruh penambahan dexmedetomidine 0.5MCG/kGbb terhadap respon hemodinamik saat intubasi endotrakeal pada pasien perdarahan intrakranial di rsud arifin achmad provinsi riau
Introduction: Endotracheal intubation in patients with intracranial hemorrhage
often triggers hemodynamic responses such as elevated blood pressure and heart
rate, which may worsen secondary brain injury. Dexmedetomidine, an α2-
adrenergic agonist, has been shown to attenuate sympathetic responses and
maintain hemodynamic stability. This study aimed to evaluate the effect of adding
dexmedetomidine 0.5 mcg/kgBW on hemodynamic responses during endotracheal
intubation in patients with intracranial hemorrhage at Arifin Achmad General
Hospital, Riau Province.
Methods: This was an analytical experimental study comparing a dexmedetomidine
group and a control group. Parameters observed included changes in systolic and
diastolic blood pressure as well as heart rate before and after intubation. Data were
analyzed using normality tests, paired sample t-tests, and intergroup comparisons.
Results: The results demonstrated that dexmedetomidine 0.5 mcg/kgBW
significantly attenuated the increase in blood pressure and heart rate compared
with the control group. This indicates that dexmedetomidine is effective as an
adjuvant to maintain hemodynamic stability during endotracheal intubation in
patients with intracranial hemorrhage.
Conclusion: Intravenous dexmedetomidine 0.5 mcg/kgBW can be considered a safe
and effective option to reduce hemodynamic responses to intubation in patients with
intracranial hemorrhage.
Keywords: dexmedetomidine, intracranial hemorrhage, endotracheal intubation,
hemodynamics
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