CD Tesis
Sintesis Analog Pirazolin Dari Fluoro Kalkon Inti Naftalen dan Uji Aktivitasnya Sebagai Antimikrob
TRI WINDARTI, NIM. 1310247102, Synthesis Pyrazoline Analogues of Fluoro Chalcone Containing Naphthalen and test of its activity as antimicrobial, Supervised and proctoring by Jasril and Hilwan Yuda Teruna.
Two of analog pyrazolines, 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole(PF CN2-4F) and 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-4,5-dihydro-1H-pyrazole (PH CN2-4F) were synthesized using glacial acetic acidas a catalyst and assisted by microwave irradiation. The stuctures of the compounds were characterized based on the interpretation of UV, FTIR, 1H-NMR,13C-NMR, COSY, HSQC and HMBC data. Yield of PF CN2-4F and PH CN2-4F were 40,57% and 67,45% respectively. Antimicrobial activity of pyrazolines was tested against B. subtilis, E. coli bacteria and C.albicans fungi. Based on the test it was shown that PF CN2-4F and PH CN2-4F were more bioactive as antibacterial than antifungal.
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