CD Skripsi

Sintesis Dan Uji Toksisitas (E)-3-(4-((E)-((4-Hidroksifenil) Imino)Metil)Fenil)-1 (2Metoksifenil)Prop-2-En-1-On

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Chalcone is a compound that has two aromatic rings in its structure and connected by 3 carbon atoms which is an unsaturated α, β carbonyl system. Chalcone conjugated is the conjugation of two bioactive molecules as one of the strategies to obtain new bioactive compounds. Conjugated chalcone is known to have biological activities such as antiviral, anticancer and antioxidant properties. Chalcone conjugate (E)-3-(4-((E)-((4-hydroxyphenyl)imino)methyl) phenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (KK-AF-2OMe) was synthesized from (E)-4-(3-(2-methoxy phenyl)-3-oxoprop-1-en-1-yl)benzaldehyde (K-2OMe) and 4-aminophenol by microwave irradiation method. The purity of the chalcone conjugate was determined by the TLC test, determination of melting point, and HPLC analysis. The structure of the chalcone conjugate was obtained from UV, FTIR, NMR, and HRMS spectroscopic studies. Synthesis of chalcone conjugate in this research was concluded with a yield 33,60%, and the toxicity was determined by the Brine Shrimp Lethality Test (BSLT) method. The value of the LC50 was showed 6,525 µg/mL. From the data above was concluded that chalcone conjugate KK-AF-2OMe was toxic.

Keywords: chalcone conjugate, 4-aminofenil, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0015)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiv, 35 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0015)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

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