CD Skripsi

Sintesis Dan Uji Toksisitas (2e,2'e)-3,3'-(1,4-Fenilen)Bis(1-(3-Metoksifenil)Prop-2-En-1-On

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Chalcone is one of the secondary metabolites of the flavonoid group that has two aromatic rings connected by three carbon α, β unsaturated, the distribution of chalcone compounds in nature is very limited but has many important biological activities. In this research, symmetric chalcone (2E, 2'E) -3.3'- (1,4-phenylene) bis (1- (3-methoxyphenyl) prop-2-en-1-on chalcone was carried out and toxicity testing of these compounds. Chalcone compound was synthesized from the aldol condensation reaction between 3-methoxyacetophenone and terepthaldialdeid which was catalyzed by the NaOH base using stirring at 0-5 0C. The purity of the coumpounds was determined using by KLT test, melting point and HPLC analysis. Compounds structure was analyzed using UV spectroscopy, FTIR, 1H-NMR, and HRMS. The yield obtained from the synthesis is 31,25 %. Compounds toxicity test K1-3OMe determined by the BSLT method using shrimp larvae (Arthemia Salina Leach). LC50 value of compounds K1-3OMe is 216,27μg/mL. Concluded that the compound K1-3OMe are not toxic.

Keywords: chalcone, flavonoid, toxicity

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0017)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiv, 34 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0017)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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