CD Skripsi

Sintesis, Molecular Docking Dan Uji Bioaktivitas Senyawa 5-(4-Fluorofenil)-3-(Naftalen-1-Il)-1-Fenil-1h-Pirazol Sebagai Antidiabetes

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Diabetes mellitus is a disease caused by the body not being able to effectively use the insulin produced by the pancreas. Pirazol is a five ring heterocyclic compound containing two nitrogen atoms. Novel compound 5-(4-fluorophenyl)-3-(naphthalene-1-yl)-1-phenyl-1H-pyrazole (PZL-4F) was successfully synthesized through synthesis of one-pot cyclization of yrazoline which was then followed by oxidative aromatization reaction. The structure was confirmed using UV-Vis, IR, HRMS and NMR spectroscopy analysis. PZL-4F was tested for antidiabetic in vitro and molecular docking. An antidiabetic test was performed to inhibit the α-glucosidase enzyme. The molecular docking study was carried out on the α-glucosidase crystal structure (PDB ID: 5NN5). The target compound has α-glucosidase inhibiting activity with IC50 628.5413 μg/mL. This compound shows the free energy of binding (S score) -12,4097 kcal/mol. PZL-4F formed the same hydrogen bond compared to positive control of acarbose with the amino acid residue Arg672, but not with Asp group. These results showed the target compound has a less good activity compared to the positive control of acarbose.
Keywords: antidiabetic, molecular docking, pyrazole, α-glucosidase

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

03 02. 120 (0021)

Penerbit

Pekanbaru : Universitas Riau – FMIPA – Kimia., 2020

Deskripsi Fisik

xiii, 37 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

03 02. 120 (0021)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KIMIA

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

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