CD Skripsi

Hubungan Polimorfisme Promoter Gen Interleukin-10 Dengan Status Hbsag Pada Donor Darah Di Pekanbaru

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Hepatitis B virus (HBV) infection is a major health problem in developing countries. HBV is transmissitted through blood and body fluid exposure from an infected person. Individuals with asymptomatic HBV infection can donate blood because there are no specific clinical symptoms of HBV infection. Hepatitis B surface antigen (HBsAg) is a serological marker for HBV infection. Polymorphisms in the IL-10 (-1082) gene promoter can contribute to the susceptibility of HBV infection. The purpose of this study was to analyze the relationship between the distribution of interleukin-10 gene polymorphisms and HBsAg status. The samples in this study were 70 blood donors from the Indonesian Red Cross (PMI) Pekanbaru consisting of 35 blood donor samples with reactive HBsAg and 35 blood donor samples with non-reactive HBsAg. The IL-10 (-1082) gene polymorphism was examined by using Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). There was no significant relationship in the mean age p = 0,381 and sex distribution (p = 0,584) between two study groups. In the case of reactive HBsAg, AA genotype distribution (62.9%), AG/GG (37.1%), and non-reactive HBsAg control, distribution of AA genotypes (85.7%), AG/GG (14,3%). There was a significant relationship between IL-10 genotype and HBsAg status (p = 0,028). Distribution of alleles in blood donors with reactive HBsAg consisted of A (81%), G (19%) and in blood donors with non-reactive HBsAg A (91%), G (9%). There was no significant relationship between allele distribution and HBsAg status (p = 0,084).


Keywords : Blood Donors, HBsAg reactive, IL-10-1082, Hepatitis B

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01.120 (0025)

Penerbit

Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter., 2020

Deskripsi Fisik

xiv, 50 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01.120 (0025)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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