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Hubungan Antara Polimorfisme Gen Interleukin-10 Dan Status Anti-Hepatitis B Surface Pada Mahasiswa Kedokteran Universitas Riau

Hepatitis B is the leading cause of death worldwide. Hepatitis B can develop into fatal liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Previous research has shown that IL-10 gene polymorphism (-1082 G / A) is associated with clinical manifestations of chronic hepatitis B virus (HBV) infection, susceptibility to HBV infection and immune response after hepatitis B vaccination. The purpose of this study was to determine the correlation between IL-10 gene polymorphism and long term immune status following hepatitis vaccination in Medical Students of Riau University. This was an analytical study with a case control research design and conducted from November 2019 to January 2020. Total of 84 samples were analysed consisting of 42 samples with non-protective and 42 samples with protective anti-HBs. Anti-HBs level were measured using Chemiluminescence Microparticle Immunoassay (CMIA) method and IL-10 gene polymorphism was detected by Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR). The results showed that 83% of subject had AA genotype and 16.7% had GA genotype while there no subjects were found to have GG genotype. In addition 91,7% had A allele and 8,3% had G allele. Statistical analysis showed that there was no significant correlation between genotype and allele distribution of IL-10 gene (-1082 G / A) polymorphism and anti-HBs status. In conclusion IL-10 (-1082 G/A) gene polymorphism was not correlated with long term immune status of hepatitis B vaccination.

Keywords : Anti-HBs Status, Alleles, Genotypes, Interleukin-10, Polymorphism

Ketersediaan
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Perpustakaan Universitas Riau 08 01.120 (0063)
08 01.120 (0063)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
08 01.120 (0063)
Penerbit
Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter.,
Deskripsi Fisik
xiii, 42 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
08 01.120 (0063)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN DOKTER
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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