CD Skripsi

Hubungan Polimorfisme Reseptor Vitamin D (Foki) Dengan Status Hbsag Pada Donor Darah Di Pekanbaru

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Hepatitis B surface antigen (HBsAg) is a serological marker for hepatitis B virus (HBV) infection. Previous studies suggested the relationship between Vitamin D receptor (VDR) gene polymorphisms and hepatitis B susceptibility. This study aimed to analyze the association between VDR gene polymorphisms (FokI) on HBsAg status among blood donor in Indonesian Red Cross Riau Province. This study was analytical research with case control design. The samples obtained from blood donors in Indonesian Red Cross Riau Province consisting of 35 HBsAg-reactive and 35 HBsAg non-reactive samples. VDR genotype detection was done using the Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) method. The distribution of FokI VDR genotypes between the two HBsAg status groups was analyzedusing Chi square test. The results of this study showed no significant difference between the mean age (p = 0.333) and gender (p = 0.780) between the two HBsAg status groups. In this study the highest frequency of FokI genotypes was Ff, 54.3% in both groups. The highest FokI allele frequency was F, 67.1% in HBsAg-reactive and 64.3% in HBsAg non-reactive groups. There was no significant difference between the distribution of FokI VDR genotypes (p = 0.643) and alleles (p = 0.722) between HBsAg reactive and non-reactive groups.


Keywords:Blood donor, FokI, Hepatitis B, VDR polymorphism

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01.120 (0072)

Penerbit

Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter., 2020

Deskripsi Fisik

xii, 50 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01.120 (0072)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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