CD Skripsi
Pengaruh Ekstrak Perepat (Sonneratia Alba) Terhadap Ketebalan Tunika Muskularis Aorta Abdominal Tikus Wistar (Rattus Norvegicus) Aterosklerosis
Perepat (Sonneratia alba) is a mangrove plant that contains high antioxidant
compounds consisting of alkaloids, flavonoids, phenolics, saponins and tannins. In
this study, we will analyze the effect of giving Sonneratia alba extract on the
thickness of the tunica muscularis aorta abdominal male white rats (Rattus
norvegicus) Wistar strain. Eighteen male Wistar rats were divided into negative
control group (I), positive control group (II) and treatment group (III). Groups II and
III were induced to atherosclerosis by giving oral vitamin D3 700,000 IU / kg and
atherogenic diet for three days. Group III was given Sonneratia alba extract 400 mg /
kgBW / day for three days. The thickness of the abdominal aortic tunica muscularis
was measured by Leica Acquired in eight microscopic fields of 400x magnification.
The results showed that the average thickness of the tunica muscularis groups I, II
and III respectively were 0.087 ± 0.009, 0.095 ± 0.012 and 0.073 ± 0.008. Statistical
analysis with One-Way ANOVA showed a significant difference (p = 0.009). Further
analysis showed a significant difference in the positive control group with treatment
(p = 0.003). Sonneratia alba extract has been shown to reduce the mean thickness of
the tunica muscularis of the abdominal aorta in the early stages of atherosclerosis.
Key words: atherosclerosis; tunica muscularis; mangroves; Sonneratia alba
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