CD Skripsi

Hubungan Kadar Vitamin D Dan Gangguan Fungsi Hati Pada Pasien Hepatitis B Kronik

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Chronic liver inflammation by hepatitis B virus (HBV) infection is a result
of immune response against viral invasion which can ultimately cause liver
dysfunction. The severity of liver dysfunction can be determined by the albuminbilirubin
ratio (ALBI). Vitamin D has been suggested to play an important role in
the pathogenesis of chronic hepatitis B (CHB) through its role in immune system
regulation. This study aimed to determine the relationship between vitamin D levels
and impaired liver function in CHB patients. This was an observational analytical
study with a cross-sectional approach conducted from March to October 2019. We
included 36 CHB patients aged 38.31 ± 12.98 years and consisted of 16 men and
20 women. Vitamin D levels were measured by enzyme-linked immune assay
(ELISA) method while albumin and bilirubin levels were examine by colorimetric
assay. The ALBI ratio was calculated using the formula of (log10 bilirubin [μmol /
L] x 0.66) + (albumin [g / L] x -0.085). The results showed that 80.6% of CHB
patients had vitamin D levels within normal limits and 19.4% experienced vitamin
D insufficiency/deficiency. Furthermore, 75% of patients showed good ALBI ratio
scores and only 25% with moderate-poor ALBI scores. Statistical analysis showed
that there was no significant relationship between vitamin D levels and the ALBI
ratio. The conclusion of this study is that there is no relationship between plasma
vitamin D levels and impaired liver function in CHB patients.
Keywords: ALBI ratio, albumin, bilirubin, chronic hepatitis B, vitamin D

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

08 01.121 (0003)

Penerbit

Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter., 2021

Deskripsi Fisik

xv, 63 hlm.: ill.: 29 cm

Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

08 01.121 (0003)

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PENDIDIKAN DOKTER

Info Detail Spesifik

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Pernyataan Tanggungjawab

ELFITRA

Versi lain/terkait

Lampiran Berkas

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