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Hubungan Polimorfisme Reseptor Vitamin D Dengan Kerusakan Hati Pada Pasien Hepatitis B Kronik Di Rsud Arifin Achmad Provinsi Riau

Hepatitis B remains an endemic disease in many countries around the world. Patients
with chronic hepatitis B (CHB) are at risk for fatal liver diseases such as cirrhosis and
hepatocellular carcinoma (HCC). Liver cell damage in hepatitis patients is caused by
the body's immune response against infected liver cells. Vitamin D regulates the body's
immune response by binding to vitamin D receptors (VDR). This study aimed to
determine the relationship between VDR polymorphism and liver damage in chronic
hepatitis B patients at Arifin Achmad Hospital, Riau Province. This study was an
observational analytical study with a cross-sectional design that was conducted from
September to December 2020. The total sample studied were 75 CHB patients consisting
of 45 men and 30 women with a mean age of 38.16 ± 12.71 years. The degree of liver
damage was categorized based on serum glutamic piruvic transaminase (SGPT) levels.
Identification of VDR gene polymorphisms using the Amplification Refractory Mutation
System-Polymerase Chain Reaction (ARMS-PCR) method. The results showed that
most of the samples had Ff genotype of 57.3%, TT of 72%, aa of 48%, bb of 74%
respectively for FokI, TaqI, ApaI and BsmI. Statistical analysis showed that there was
no significant relationship between VDR gene polymorphisms and liver damage. The
conclusion of this study is that there is no significant relationship between VDR
polymorphism and liver damage in chronic hepatitis B patients at Arifin Achmad
Hospital, Riau Province.
Keywords : Chronic Hepatitis B, Liver Damage, Polymorphism, Vitamin D Receptor

Ketersediaan
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Perpustakaan Universitas Riau 08 01.121 (0004)
08 01.121 (0004)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
08 01.121 (0004)
Penerbit
Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter.,
Deskripsi Fisik
xv, 62 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
08 01.121 (0004)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN DOKTER
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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