Image of Efek Inhibitor Proteasom Terhadap Histopatologi Aorta Torakalis Pada Tikus Model Aterosklerosis
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Efek Inhibitor Proteasom Terhadap Histopatologi Aorta Torakalis Pada Tikus Model Aterosklerosis

Proteasomes are large protein complexes responsible for the degradation of
intracellular proteins other than lysosomes through the ubiquitin-proteasome
system. Previous studies have shown an increase in proteasome expression at
each stage of atherosclerosis, especially at the progression stage. This study aims
to analyxe the effects of proteasome inhibitor that is called bortezomib on
atheroclerosis lesion in the thoracic aorta of atherosclerosis models.This
experimental research uses 18 rats (rattus novergicus) male wistar strain that is
divided into control group (I), atherosclerosis group (II), and atherosclerosis with
bortezomib group (III). Atherosclerosis induction is done by giving vitamin D3
(700.000 IU/KgBB) orally by means of gastric intubation on day 1 and
atherogenic feed in the form of (2% cholesterol, 5% goat fat, 0.2% cholic acid)
for 4 days. Low doses of bortezomib (50 μg/kgBB)is given two times which is the
first and third day intraperitoneally. Thoracic aortic histopatological assessment
was carried out using a scoring system. The results showed that the highest mean
score of lesions was in the atherosclerosis group, namely 1.37 and the lowest in
the control group, namely 0.06. There was a decrease in the score of
atherosclerotic lesions with the administration of bortezomib with an average
score of 0.61, altough statistically it has not shown significant result.
Keywords: Atheroslerosis, Bortezomib, Proteasom, Thoracic Aorta

Ketersediaan
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Perpustakaan Universitas Riau 08 01.121 (0011)
08 01.121 (0011)
Tersedia
Informasi Detail
Judul Seri
-
No. Panggil
08 01.121 (0011)
Penerbit
Pekanbaru : Universitas Riau – Kedokteran – Pendidikan Dokter.,
Deskripsi Fisik
xv, 53 hlm.: ill.: 29 cm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
08 01.121 (0011)
Tipe Isi
-
Tipe Media
-
Tipe Pembawa
-
Edisi
-
Subjek
PENDIDIKAN DOKTER
Info Detail Spesifik
-
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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