Endometrial cancer is a malignancy from the epithelial lining of the uterus and ranks as the sixth most common cancer among women worldwide. DNA damage plays an important role in carcinogenesis, especially in endometrial cancer, thereby requiring DNA repair mechanisms in which the X-ray Repair Cross-Complementing 1 (XRCC1) gene takes a pivotal role in maintaining genomic stability through the b…
Adenomyosis is a benign gynecological disorder characterized by the presence of endometrial glands and stroma within the myometrium, frequently associated with infertility. Reduced endometrial receptivity in adenomyosis has been linked to the downregulation of key implantation markers, including HOXA10. Curcumin was known to exert anti-inflammatory effects primarily through inhibition of the NF…
In the context of life, quality of life is an important aspect that must be maintained in order to live well. This quality of life is particularly influential among patients with hypertension, and to maintain it, they are required to engage in physical activity to help regulate blood pressure and promote calorie burning in the body. This study was conducted at the Internal Medicine Clinic of Ar…
Hypertension is a significant public health concern with rising prevalence and serves as a primary risk factor for cardiovascular diseases. This study aimed to analyze the risk factors associated with the incidence of hypertension in the Dumai City community. This study utilized an analytical cross-sectional design with 708 respondents. Data analysis was performed using univariate, bivariate wi…
Adenomyosis, characterized by the invasion of endometrial tissue into the myometrium resulting in myometrial hypertrophy, is a gynecological disorder that requires new therapeutic approaches. This study aimed to evaluate the therapeutic potential of Nano-Curcumin, a high-bioavailability formulation possessing potent anti-inflammatory properties, against adenomyosis parameters in a rat model. Th…
Sharp force injury is an act that causes partial or complete tissue damage to the human body resulting from the use of a sharp object. According to data from the Badan Pusat Statistik (BPS), the crime rate in Indonesia continues to increase. Visum et Repertum (VeR) is an official document that contains descriptions of injuries which can be used as evidence in court. This study aimed to determin…
Endometriosis is an estrogen–dependent gynecological disease characterized by the growth of ectopic endometrial tissue and was one of the causes of infertility. This condition affected reproductive health, while local data were still limited. The prevalence of infertility among endometriosis patients at Arifin Achmad General Hospital increased significantly from 12.8% (2012–2016) to 54.1% (…
Violence is an intentional act that causes pain and injury to a person, both physically and psychologically. One of the most common types of violence treated at Bhayangkara Hospital is blunt force trauma. Blunt force trauma is a condition where the body is injured or harmed by a hard impact with a blunt object. This study aims to determine the profile of cases of live victims of blunt force tra…
Anemia is a pathological condition characterized by a decrease in hemoglobin levels below the normal range. Anemia among adolescent girls remains a common health issue caused by various factors, one of which is Chronic Energy Deficiency (CED). This study aimed to determine the relationship between Chronic Energy Deficiency and indications of anemia among adolescent girls at SMA Negeri Pintar, K…
Type II Diabetes Mellitus is a non-communicable disease with an increasing prevalence in Indonesia, including Dumai City. Early detection through the PTM SATUSEHAT screening program is essential to identify its risk factors. This study aimed to analyze the risk factors associated with random blood glucose levels among Dumai City community based on PTM SATUSEHAT screening data. The type of this …
Diabetes Mellitus (DM) is a state of hyperglycemia that triggers oxidative stress that can cause liver damage characterized by reversible and irreversible damage to hepatocyte cells. Sugar palm leaf (Arenga pinnata) extract contains flavonoid compounds which have antidiabetic effects. This study aims to determine the effect of administering sugar palm leaf extract (Arenga pinnata) on the histop…
Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in carbohydrate, fat, and protein metabolism resulting from impaired insulin secretion, insulin action, or both. Elevated blood glucose levels (hyperglycemia) are the hallmark of DM. This study aimed to evaluate the effect of Arenga pinnata leaf extract on the histopathological features of the gastric mucosa in streptozotoci…
Adolescent obesity is a major health problem that contributes to various metabolic disorders, including elevated blood glucose levels. Adequate and regular physical activity plays an important role in preventing obesity and maintaining normal blood glucose levels. In Riau Province, particularly in Pekanbaru, the prevalence of adolescent obesity increased from 3.1% in 2013 to approximately 11.6%…
Sea cucumber is one of the marine commodities originating from Karimun Regency. Sea cucumber is made into flour and then extracted. Extraction of sea cucumber using methanol solution. The methanol extract is then fractionated using three solutions based on their polarity, namely n-hexane, ethyl acetate, and ethanol. The test parameters in this study were water content, fat, secondary metabolite…
This study aims to determine the moisture content, ash content, and sulfate content of Sargassum sp. flour, the extract yield, functional groups, spectral patterns, fucoxanthin content, and antioxidant activity of crude fucoxanthin extract from Sargassum sp. The method used was acomplete randomized design (CRD)non-factorial 3-level treatment experiment using ethanol, acetone, and n-hexane solve…
This study aimed to identify the secondary metabolites contained in the extract of berunok sea cucumber (Paracaudina australis) and to evaluate its in-vitro anti-cholesterol activity. Berunok sea cucumber is one of Indonesia‟s marine biota with potential as a natural source of bioactive compounds that can help prevent degenerative diseases. The extraction was carried out using the maceration …
ABSTRACT The activity of loading fresh fruit bunches (FFB) in PT XYZ is still carried out manually using simple tools such as a T-hook or tojok. Non-ergonomic working postures and heavy physical workload have the potential to cause Musculoskeletal Disorders (MSDs). This study aims to analyze the level of postural risk using the Rapid Upper Limb Assessment (RULA) method assisted by the Ergo…
ABSTRACT The waste management issue in Binawidya District remains a challenge due to low public awareness of paying waste service retribution fees. This condition has the potential to hinder the sustainability of an effective waste management system. This study aims to analyze the community’s Willingness To Pay (WTP) and Ability To Pay (ATP), as well as identify the factors that influenc…
ABSTRACT Storage tanks are storage containers frequently used in various industries such as petrochemical, refining, petroleum, and others. The reliability of storage tanks is crucial because structural failures can result in serious consequences. The purpose of this study is to evaluate the operational feasibility of tanks with shell distortion defects in the form of arbitrary out of roundnes…
ABSTRACT A construction project has specific objectives that must be met, namely on-time, onbudget, and on-quality, as well as safety in the construction process. These objectives will be met if there is good management, one of which is project time management. This study aims to evaluate the application of Project Time Management (PTM) in construction projects carried out by contractors i…