SUMMARY Diplazium esculentum is a species of fern belonging to the Athyriaceae family which can be used as a medicinal plant, one of which is suspected of being a potential inhibitor of α-amylase and α-glucosidase enzymes. This study aims to determine the relationship between the total flavonoids and phenolics content in the ethyl acetate and water extract of D. esculentum and their ability …