CD Tesis

aktivitas antiinflamasi ekstrak daun nanas kerang (tRADESCANTIA SPATHACEA sW.) pada hewan model hemoroid

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Background: Hemorrhoid is anorectal disorder characterized by venous dilation and increased levels of inflammatory mediators such as IL-6 and COX-2. Therapy with NSAIDs can cause gastrointestinal side effects, highlighting the need for safer alternatives. Tradescantia spathacea (oyster plant) is known to contain flavonoids and phenolic compounds with anti‑inflammatory effects.
Methods: This experimental study used a rat model of hemorrhoids induced by 6% croton oil. The rats were divided into five groups: normal, negative control, positive control (Aspirin 5 mg/kgBW), and two treatment groups receiving T. spathacea leaf extract at 200 and 400 mg/kgBW for 7 days. Macroscopic and microscopic evaluations of anorectal tissue were conducted, including venule diameter measurement. COX‑2 and IL‑6 mRNA expression was analyzed by RT‑qPCR, while protein expression was assessed via immunohistochemistry. Statistical analyses were performed using one‑way ANOVA and post‑hoc tests for normally distributed data, and non‑parametric tests for data that were not normally distributed.
Results: Administration of T. spathacea leaf extract (200 and 400 mg/kgBW) significantly reduced venule diameter (p

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

2310246494

Penerbit

Pekanbaru : UNRI – PASCA – Magister Ilmu Biomedis., 2025

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

2310246494

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Magister Ilmu Biomedis

Info Detail Spesifik

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Pernyataan Tanggungjawab

Rahmat

Versi lain/terkait

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