Endometrial cancer is a malignancy from the epithelial lining of the uterus and ranks as the sixth most common cancer among women worldwide. DNA damage plays an important role in carcinogenesis, especially in endometrial cancer, thereby requiring DNA repair mechanisms in which the X-ray Repair Cross-Complementing 1 (XRCC1) gene takes a pivotal role in maintaining genomic stability through the b…
Adenomyosis is a benign gynecological disorder characterized by the presence of endometrial glands and stroma within the myometrium, frequently associated with infertility. Reduced endometrial receptivity in adenomyosis has been linked to the downregulation of key implantation markers, including HOXA10. Curcumin was known to exert anti-inflammatory effects primarily through inhibition of the NF…
In the context of life, quality of life is an important aspect that must be maintained in order to live well. This quality of life is particularly influential among patients with hypertension, and to maintain it, they are required to engage in physical activity to help regulate blood pressure and promote calorie burning in the body. This study was conducted at the Internal Medicine Clinic of Ar…
Hypertension is a significant public health concern with rising prevalence and serves as a primary risk factor for cardiovascular diseases. This study aimed to analyze the risk factors associated with the incidence of hypertension in the Dumai City community. This study utilized an analytical cross-sectional design with 708 respondents. Data analysis was performed using univariate, bivariate wi…
Adenomyosis, characterized by the invasion of endometrial tissue into the myometrium resulting in myometrial hypertrophy, is a gynecological disorder that requires new therapeutic approaches. This study aimed to evaluate the therapeutic potential of Nano-Curcumin, a high-bioavailability formulation possessing potent anti-inflammatory properties, against adenomyosis parameters in a rat model. Th…
Sharp force injury is an act that causes partial or complete tissue damage to the human body resulting from the use of a sharp object. According to data from the Badan Pusat Statistik (BPS), the crime rate in Indonesia continues to increase. Visum et Repertum (VeR) is an official document that contains descriptions of injuries which can be used as evidence in court. This study aimed to determin…
Endometriosis is an estrogen–dependent gynecological disease characterized by the growth of ectopic endometrial tissue and was one of the causes of infertility. This condition affected reproductive health, while local data were still limited. The prevalence of infertility among endometriosis patients at Arifin Achmad General Hospital increased significantly from 12.8% (2012–2016) to 54.1% (…
Violence is an intentional act that causes pain and injury to a person, both physically and psychologically. One of the most common types of violence treated at Bhayangkara Hospital is blunt force trauma. Blunt force trauma is a condition where the body is injured or harmed by a hard impact with a blunt object. This study aims to determine the profile of cases of live victims of blunt force tra…
Anemia is a pathological condition characterized by a decrease in hemoglobin levels below the normal range. Anemia among adolescent girls remains a common health issue caused by various factors, one of which is Chronic Energy Deficiency (CED). This study aimed to determine the relationship between Chronic Energy Deficiency and indications of anemia among adolescent girls at SMA Negeri Pintar, K…
Type II Diabetes Mellitus is a non-communicable disease with an increasing prevalence in Indonesia, including Dumai City. Early detection through the PTM SATUSEHAT screening program is essential to identify its risk factors. This study aimed to analyze the risk factors associated with random blood glucose levels among Dumai City community based on PTM SATUSEHAT screening data. The type of this …
Diabetes Mellitus (DM) is a state of hyperglycemia that triggers oxidative stress that can cause liver damage characterized by reversible and irreversible damage to hepatocyte cells. Sugar palm leaf (Arenga pinnata) extract contains flavonoid compounds which have antidiabetic effects. This study aims to determine the effect of administering sugar palm leaf extract (Arenga pinnata) on the histop…
Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in carbohydrate, fat, and protein metabolism resulting from impaired insulin secretion, insulin action, or both. Elevated blood glucose levels (hyperglycemia) are the hallmark of DM. This study aimed to evaluate the effect of Arenga pinnata leaf extract on the histopathological features of the gastric mucosa in streptozotoci…
Adolescent obesity is a major health problem that contributes to various metabolic disorders, including elevated blood glucose levels. Adequate and regular physical activity plays an important role in preventing obesity and maintaining normal blood glucose levels. In Riau Province, particularly in Pekanbaru, the prevalence of adolescent obesity increased from 3.1% in 2013 to approximately 11.6%…
Trauma is one of the causes of morbidity and mortality worldwide. In addition to sharp and blunt force injuries, there are various other forms of trauma that can also cause serious injuries, such as thermal, electrical, explosive, and chemical trauma. This study aims to determine the profile of living victims of trauma other than sharp and blunt force injuries examined at Bhayangkara Hospital P…
Dyslipidemia is one of the lipid metabolism disorders characterized by an increase in Low-Density Lipoprotein (LDL) levels in the blood. Seri leaf (Muntingia calabura) is known to contain active compounds such as flavonoids and saponins that have potential hypolipidemic effects. This study aimed to determine the effect of seri leaf extract administration on LDL levels in Wistar rats fed a High …
Infection by soil-transmitted helminths is one of the most common forms of infection affecting elementary school-aged children. The worms that commonly cause infection are roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus). This descriptive cross-sectional study was conducted from January to August 2025 in eight eleme…
Bladder cancer is a malignancy originating from urothelial cells lining the inner surface of the bladder and is one of the most common urological cancers, particularly in elderly males. Risk factors include smoking, exposure to industrial chemicals, and chronic urinary tract infections. Early symptoms such as hematuria and dysuria are often overlooked, leading to delayed diagnosis. Cystectomy i…
Intestinal protozoa are unicellular eukaryotic microorganisms inhabiting the human gastrointestinal tract and are capable of causing infections. Transmission occurs through the ingestion of cysts or oocysts present in contaminated food or water. In Indonesia, raw vegetables are commonly consumed as “lalapan,” including cabbage, lettuce, and basil which are at risk of contamination during di…
Sepsis is characterized by a dysregulated immune response to infection, leading to life-threatening organ dysfunction. This condition poses an economic burden to nations due to its high mortality rate. The accurate selection of empirical antibiotics is a critical component in the management of sepsis. Inappropriate antibiotic use carries the risk of resistance, which can subsequently increase h…
The research problem in this study is how the implementation of caregiver services for children at Rumah Bahagia Pelita Kasih Orphanage, Payung Sekaki District, Pekanbaru, is carried out. The purpose of this study is to find out how caregivers provide services to children at the orphanage. This research focuses on three indicators: (1) Interaction, (2) Activity, and (3) Foster Children’s Sati…