Endometrial cancer is one of the most common gynecological malignancies, with a steadily increasing incidence worldwide. This cancer is characterized by the accumulation of unrepaired DNA damage that leads to genomic instability. One of the key pathways maintaining genomic stability is the homologous recombination repair (HRR) mechanism, in which the RAD51 gene plays a central role in repairing…
Endometrial cancer is a gynecological malignancy with an incidence rate that continues to increase annually. This indicates the importance of further understanding endometrial cancer, especially regarding its pathogenesis. One gene that plays a crucial role in its pathogenesis is the CHEK2 gene. Checkpoint kinase 2 (CHEK2) is a gene that plays a crucial role in the DNA damage response mechanism…
The double burden of malnutrition is the simultaneous occurrence of undernutrition and overnutrition, a condition that is trending among adolescents. One of the nutritional problems resulting from this is obesity and iron deficiency anemia. Iron deficiency anemia itself is influenced by protein intake. This study aims to analyze the characteristics, description of protein intake, hemoglobin lev…
Sepsis is a medical emergency with high morbidity and mortality, demanding optimal management, including the adjustment of definitive antibiotics based on culture and sensitivity results. This retrospective descriptive study aims to provide an overview of culture results and the pattern of definitive antibiotic therapy use in 57 sepsis patients treated at the Intensive Care Unit (ICU) of RSUD A…
The sugar palm (Arenga pinnata) is well known for its sap, which is processed into palm sugar. Leave extract of this tree also possesses potential antidiabetic properties that may help regulate blood glucose levels. Previous studies have shown that the phytochemical compounds contained in A. pinnata leaves such as flavonoids, alkaloids, tannins, and triterpenoids have the potential to reduce bl…
Carpal Tunnel Syndrome (CTS) is a common median nerve compression neuropathy. Nerve conduction studies (NCS) are the objective diagnostic standard for assessing nerve function. To date, no data has described the NCS findings in CTS patients in Riau Province. This study aimed to describe the nerve conduction study findings in Carpal Tunnel Syndrome patients in Riau Province for the 2023— 2025 …
Immune Thrombocytopenic Purpura (ITP) is an autoimmune disease characterized by persistent thrombocytopenia resulting from platelet destruction and impaired thrombopoiesis. The aim of this study was to determine the clinical profile and treatment outcomes of ITP patients at Arifin Achmad Regional General Hospital from 2022 to 2024. This study employed a cross-sectional descriptive design using …
Appendicitis is an inflammatory process of the appendix and is one of the common causes of acute abdominal pain that often leads patients to seek care in the emergency department. In 2021, there were approximately 17 million new cases of appendicitis worldwide, with a mortality total of 29,300 deaths. In adults, appendiceal obstruction is generally caused by fecaliths, whereas in children it is…
Atherosclerosis is a chronic inflammatory disease caused by endothelial dysfunction and lipid accumulation, which can be triggered by a high-fat diet. This study aimed to assess the effect of kersen leaf extract (Muntingia calabura) on the degree of atherosclerosis in male Wistar rats, histopathologically. Fifteen rats were randomly divided into three groups (n=5): P1 (standard diet), P2 (high-…
Inulin is a natural polysaccharide that can enhance glucose metabolism and reduce cholesterol levels through the formation of short-chain fatty acids. These effects are thought to prevent atherosclerosis, one of the chronic complications of type 2 diabetes mellitus (T2DM). This study aimed to determine the effect of inulin extract from dahlia tubers on the thickness of the thoracic aorta intima…
Lumbar Spinal Stenosis (LSS) is caused by narrowing of the vertebral canal due to degenerative changes in the intervertebral discs, facet joints, and ligamentum flavum, leading to clinical symptoms such as low back pain and neurogenic claudication resulting from nerve or vascular compression. This study aims to identify the general profile and functional status of postoperative Lumbar Spinal St…
Education plays a crucial role in advancing a nation to be able to adapt to the demands of 21st-century education, which requires students to master science process skills. Learning biology involves direct observation of the objects under study through laboratory or field practical activities. Biology practicum requires a guide that is designed in alignment with the curriculum and the demands o…
21st-century education emphasizes the integration of technology in the learning process to foster the development of essential skills such as critical thinking, creativity, collaboration, and communication. However, students' critical thinking and science process skills are still relatively low, particularly in comprehending abstract biological topics like the human circulatory system. Observat…
Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia that leads to endothelial dysfunction and accelerates atherosclerosis. Vascular Cell Adhesion Molecule-1 (VCAM-1) plays a key role in this process. Inulin, a prebiotic fiber from dahlia tubers, has anti-inflammatory properties through inhibition of the NF-κB pathway. This experimental study aimed to evaluat…
Diabetes mellitus is a chronic disease with a high prevalence in the working area of Puskesmas Tualang. Traditional medicine is often considered safe and associated with minimal side effects. This quantitative descriptive study aims to identify the patterns of traditional medicine use among 71 respondents with diabetes mellitus. Data were collected using a questionnaire covering the types of pl…
Adolescence is a critical period for nutritional needs, as it is characterized by significant physical, psychological, and social growth and development. One of the main features of this phase in females is the onset of menstruation. Nutritional status plays an important role in menstrual patterns, both through adequate nutrition for endometrial regeneration and its influence on reproductive ho…
Adolescence is a vulnerable period to nutritional status disorders due to the increased need for nutrients to sustain rapid growth and development. An imbalance in nutritional status during this period can lead to malnutrition, which can affect growth, development, and overall health in adolescent. This research aims to describe the nutritional status of adolescent girls at SMAN Pintar Kuantan …
One of the goals of education is to create a conducive learning environment for students. In history instruction, in particular, teachers must be able to capture students' attention through innovative use of learning media. This study then developed infographic-based learning media with the topic of colonialism in Indonesia. The research method used was Research and Development (R&D). The subje…
This study aims to examine the effect of the game-based learning (GBL) model on the cognitive learning outcomes of 11th grade students in history at SMA Negeri 8 Pekanbaru. This study uses a quantitative approach with a quasi-experimental design using a pretest-posttest control group design. The sample consisted of two classes: the experimental class XI.8 with 35 students taught using the game-…
This research aims to develop a learning medium called History Uno Cards for the material on colonialism and Indonesian resistance, with the goal of increasing the learning motivation of 11th-grade students at SMAIT Al Fityah Pekanbaru. The background of the problem is the low motivation to study history due to conventional teaching methods that are monotonous and still text-book-centered. To a…