Endometrial cancer is a malignancy originating from the epithelial lining of the uterus. Previous studies have reported that dysregulation of the DNA mismatch repair (MMR) system occurs in more than 30% of endometrial cancer cases, with Muts Homolog 2 (MSH2) gene become the MMR gene with the highest mutation rate. The high mutation frequency and the crucial role of the MSH2 gene in the early st…
Lumbar spinal stenosis (LSS) is a condition of narrowing of the spinal canal in the lumbar region that causes cauda equina syndrome. Surgery aims to restore patient’s function and quality of life. This study aims to determine the clinical outcomes of LSS patients after surgery at Arifin Achmad General Hospital Riau Province using the EQ-5D-5L questionnaire. A single-arm retrospective cohort s…
Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by the accumulation of triglycerides >5% in hepatocytes. In Indonesia, the prevalence reaches 51%. Dietary interventions and functional foods are widely studied approaches as prevention strategies. Puduong, a traditional fermented food made from Pangasius sp., contains protein hydrolysates rich in bioactive peptides…
During the COVID-19 pandemic, post-mortem examinations required major procedural adjustments to ensure staff safety while maintaining the quality of forensic services. This mixed-methods study aimed to describe the characteristics of post-mortem cases handled at the Forensic Medicine and Health Division of the Riau Regional Police from 2020 to 2022, and to explore the experiences and challenges…
Mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to proliferate, differentiate, and immunomodulate. Mesenchymal stem cells produce biological coumpounds such as growth factors, cytokines, and chemokines, which have high therapeutic potential for various diseases. This study was motivated due to the high zoonotic potential and ethical concerns associated with the use of …
Central post stroke pain (CPSP) is a common yet often underdiagnosed complication of stroke that markedly affects survivors’ quality of life. This study aimed to determine the incidence and describe the clinical and pain characteristics of patients with CPSP at Arifin Achmad General Hospital, Riau Province, during 2023–2025. A descriptive cross-sectional design was applied involving 270 str…
Central post-stroke pain (CPSP) is a chronic neurological complication that significantly affects the quality of life of stroke survivors. It results from damage to central sensory pathways such as the thalamus, brainstem, and sensory cortex. This study aimed to describe the lesion locations in patients with CPSP at Arifin Achmad General Hospital, Riau Province, during the 2023–2025 period. T…
Endometrial cancer is a malignancy from the epithelial lining of the uterus and ranks as the sixth most common cancer among women worldwide. DNA damage plays an important role in carcinogenesis, especially in endometrial cancer, thereby requiring DNA repair mechanisms in which the X-ray Repair Cross-Complementing 1 (XRCC1) gene takes a pivotal role in maintaining genomic stability through the b…
Adenomyosis is a benign gynecological disorder characterized by the presence of endometrial glands and stroma within the myometrium, frequently associated with infertility. Reduced endometrial receptivity in adenomyosis has been linked to the downregulation of key implantation markers, including HOXA10. Curcumin was known to exert anti-inflammatory effects primarily through inhibition of the NF…
In the context of life, quality of life is an important aspect that must be maintained in order to live well. This quality of life is particularly influential among patients with hypertension, and to maintain it, they are required to engage in physical activity to help regulate blood pressure and promote calorie burning in the body. This study was conducted at the Internal Medicine Clinic of Ar…
Hypertension is a significant public health concern with rising prevalence and serves as a primary risk factor for cardiovascular diseases. This study aimed to analyze the risk factors associated with the incidence of hypertension in the Dumai City community. This study utilized an analytical cross-sectional design with 708 respondents. Data analysis was performed using univariate, bivariate wi…
Adenomyosis, characterized by the invasion of endometrial tissue into the myometrium resulting in myometrial hypertrophy, is a gynecological disorder that requires new therapeutic approaches. This study aimed to evaluate the therapeutic potential of Nano-Curcumin, a high-bioavailability formulation possessing potent anti-inflammatory properties, against adenomyosis parameters in a rat model. Th…
Sharp force injury is an act that causes partial or complete tissue damage to the human body resulting from the use of a sharp object. According to data from the Badan Pusat Statistik (BPS), the crime rate in Indonesia continues to increase. Visum et Repertum (VeR) is an official document that contains descriptions of injuries which can be used as evidence in court. This study aimed to determin…
Endometriosis is an estrogen–dependent gynecological disease characterized by the growth of ectopic endometrial tissue and was one of the causes of infertility. This condition affected reproductive health, while local data were still limited. The prevalence of infertility among endometriosis patients at Arifin Achmad General Hospital increased significantly from 12.8% (2012–2016) to 54.1% (…
Violence is an intentional act that causes pain and injury to a person, both physically and psychologically. One of the most common types of violence treated at Bhayangkara Hospital is blunt force trauma. Blunt force trauma is a condition where the body is injured or harmed by a hard impact with a blunt object. This study aims to determine the profile of cases of live victims of blunt force tra…
Anemia is a pathological condition characterized by a decrease in hemoglobin levels below the normal range. Anemia among adolescent girls remains a common health issue caused by various factors, one of which is Chronic Energy Deficiency (CED). This study aimed to determine the relationship between Chronic Energy Deficiency and indications of anemia among adolescent girls at SMA Negeri Pintar, K…
Type II Diabetes Mellitus is a non-communicable disease with an increasing prevalence in Indonesia, including Dumai City. Early detection through the PTM SATUSEHAT screening program is essential to identify its risk factors. This study aimed to analyze the risk factors associated with random blood glucose levels among Dumai City community based on PTM SATUSEHAT screening data. The type of this …
Diabetes Mellitus (DM) is a state of hyperglycemia that triggers oxidative stress that can cause liver damage characterized by reversible and irreversible damage to hepatocyte cells. Sugar palm leaf (Arenga pinnata) extract contains flavonoid compounds which have antidiabetic effects. This study aims to determine the effect of administering sugar palm leaf extract (Arenga pinnata) on the histop…
Diabetes mellitus (DM) is a metabolic disorder caused by abnormalities in carbohydrate, fat, and protein metabolism resulting from impaired insulin secretion, insulin action, or both. Elevated blood glucose levels (hyperglycemia) are the hallmark of DM. This study aimed to evaluate the effect of Arenga pinnata leaf extract on the histopathological features of the gastric mucosa in streptozotoci…
Adolescent obesity is a major health problem that contributes to various metabolic disorders, including elevated blood glucose levels. Adequate and regular physical activity plays an important role in preventing obesity and maintaining normal blood glucose levels. In Riau Province, particularly in Pekanbaru, the prevalence of adolescent obesity increased from 3.1% in 2013 to approximately 11.6%…