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pengaruh pemberian nano kurkumin terhadap ekspresi cyclooxygenase-2 dan inter…
Hemorrhoid is anorectal disorder characterized by venous dilation, inflammation, and structural damage to the supporting tissues of the anus. Inflammatory mediators such as COX-2 (pro-inflammatory) and IL-10 (anti-inflammatory) play key roles in their pathogenesis and serve as biomarkers for disease progression and therapeutic response. Curcumin, the active compound in turmeric, has known anti-…
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aktivitas antiinflamasi ekstrak daun nanas kerang (tRADESCANTIA SPATHACEA sW.…
Background: Hemorrhoid is anorectal disorder characterized by venous dilation and increased levels of inflammatory mediators such as IL-6 and COX-2. Therapy with NSAIDs can cause gastrointestinal side effects, highlighting the need for safer alternatives. Tradescantia spathacea (oyster plant) is known to contain flavonoids and phenolic compounds with anti‑inflammatory effects. Methods: This …
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modifikasi kultur sel punca mesenkimal dengan kombinasi kondisi hipoksia dan …
Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapies, particularly for the treatment of degenerative diseases. Various strategies have been developed to enhance the therapeutic potential of MSCs, including culture modification or preconditioning. Hypoxia and lipopolysaccharide (LPS) exposure individually have been reported to affect cell viability, proliferatio…
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Analisis Hubungan Variasi Genetik Gen L1 Dan L2 Human Papillomavirus Tipe 16 …
Introduction: Cervical cancer is a malignancy of the cervix caused by persistent infection with human papillomavirus (HPV), particularly types 16 and 18. It is the second most common cancer among Indonesian women, with a 56% mortality rate. The L1 and L2 genes encode capsid proteins used to form virus-like particles (VLPs) in HPV vaccines. This study aimed to analyze genetic variations in the L…
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Analisis Aktivitas Anti Inflamasi Nanokurkumin Terhadap Ekspresi Il-10 Dan Co…
Background: Adenomyosis is a benign gynecological condition characterized by the invasion of endometrial tissue into the myometrium, with a prevalence of 10-65% in women of reproductive age. Its symptoms include dysmenorrhea, heavy menstrual bleeding, and infertility, all of which significantly impact the quality of life. Chronic inflammation plays a key role in its pathogenesis, marked by incr…
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efek antiinflamasi sapropterin terhadap nitric oxide synthase 3, cox-2, il-10…
Hemorrhoids are anorectal disorders characterized by venous dilation and mucosal inflammation. Recent genomic analyses identify nitric oxide synthase-3 (NOS3) as a key risk gene; sapropterin—an FDA-approved 6-R-tetrahydrobiopterin analog for phenylketonuria—is predicted to down-regulate this pathway. Objective: To evaluate the anti-inflammatory effect of sapropterin on NOS3, cyclo-oxygenas…
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- 2110247752
pengaruh prakondisi vitamin d3 terhadap viabilitas, antioksidan dan apoptosis…
Mesenchymal stem cells (MSCs) are well known for their significant therapeutic potential due to several key biological characteristics. However, MSCs have a limited lifespan during in vitro expansion. This limitation is primarily due to the accumulation of reactive oxygen species (ROS), which triggers oxidative stress and can potentially damage biomolecules within MSCs. The objective of this st…
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- 2110247770
hubungan persentase metilasi dna dan ekspresi Mrna gen mesoderm spesific tran…
Male infertility is a significant reproductive health issue often associated with sperm quality. One approach to understanding its molecular mechanism is by exploring epigenetic regulation, particularly DNA methylation and gene expression. MEST is an imprinted gene essential for spermatogenesis and has been implicated in infertility, especially in oligozoospermia. Methods: This case contro…
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- 2110247734
hubungan tingkat metilasi dna dan ekspresi Mrna gen h19 pada pasien oligozoos…
Oligozoospermia, occurs in 34.14% of male infertility cases, define as sperm concentration counted less than 15 million sperm/mL/ejaculation. One of the factor that affects sperm concentration is epigenetic factors, including DNA methylation. We hypotized that sperm concentration is affected by the DNA methylation of H19 gene, a significant gene in fetal growth and development, especially in th…
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Efek Kombinasi Hipoksia dan Interferon-ℽ terhadap Viabilitas, Migrasi dan E…
Background: Mesenchymal stem cells (MSCs) have great potential for therapy due to their self-renewal, differentiation and immunoregulatory capacities. The proliferative and functional activity of MSCs as well as its immunomodulatory properties can be impaired as a result of oxidative stress-induced senescence during long-term culture of MSCs. Modification of MSCs culture is very important to im…
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Efek Prakondisi Vitamin D terhadap Karakteristik Biologis dan Ekspresi Tumor …
VITRIYANNA MUTIARA YUHENDRI. NIM. 2110247804. The Effect of Vitamin D Preconditioning on Biological Characteristics and Expression of Tumor Necrosis Factor-α, Interleukin-6, Vascular Endothelial Growth Factor in Mesenchymal Stem Cells. supervised by Arfianti and Ismawati. Background: Mesenchymal stem cells (MSCs) have great potential in regenerative medicine applications. Vitamin D has immuno…
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Efek Anti Inflamasi Metformin Melalui Perubahan Cyclooxygenase-2 (COX-2) dan …
NURUL AZIZAH, Student ID: 2210246766, The Anti-Inflammatory Effect of Metformin Through Modulation of Cyclooxygenase-2 (COX-2) and Interleukin-10 (IL-10) in a Hemorrhoid Rat Model, supervised by Dr. Darmawi M.Biomed., PhD, and Dr. M. Yulis Hamidy, M.Kes, M.Pd.Ked., Sp.K.K.L.P. Background: Hemorrhoids are a medical condition characterized by inflammation and dilation of blood vessels around the…
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Analisis Efek Antiinflamasi Metformin Melalui Perubahan Ekspresi Tumor Necro…
Hemorrhoids are a condition characterized by the dilation of venous blood vessels in the anorectal region, involving inflammation, thrombosis, and bleeding. Anti-inflammatory treatments are crucial in preventing the progression of hemorrhoids. Metformin, primarily used as an antihyperglycemic drug, also has anti-inflammatory properties. Its use in patients with type 2 diabetes shows potential i…
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- 2210246767
Uji mekanisme kerja antibakteri Turunan diterpen kuinon pada bakteri Gram pos…
Introduction: Diterpene quinone-derived compounds are proven to have antibacterial activity. However, their mechanism of action is unknown. This study aims to determine the mechanism of antibacterial action of a diterpene quinone derivatives (67DOR, 6O7AR) on S. aureus and E. coli through in vitro and in silico assays. Methods: This study is a laboratory experimental through in vitro and in si…
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